Evaluation of Vancomycin Dosing and Corresponding Drug Concentrations in Pediatric Patients
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چکیده
ABBREVIATIONS AUC: area under the curve IDSA: Infectious Diseases Society of America MIC: minimum inhibitory concentration MRSA: methicillin-resistant Staphylococcus aureus SCr: serum creatinine VIN: vancomycin-induced nephrotoxicity Dr Geerlof wrote the fi rst draft of the manuscript and made substantive contributions to the study; Dr Boucher made substantive contributions to the study; and both authors approved the fi nal manuscript as submitted. www.hospitalpediatrics.org doi:10.1542/hpeds.2014-0019 Address correspondence to Lauren Maurer Geerlof, PharmD, BCPS, Lehigh Valley Health Network, 1200 South Cedar Crest Boulevard, Inpatient Pharmacy, Allentown, Pennsylvania. E-mail: [email protected] HOSPITAL PEDIATRICS (ISSN Numbers: Print, 2154 1663; Online, 2154 1671). Copyright © 2014 by the American Academy of Pediatrics
منابع مشابه
A Prospective Study to Assess Vancomycin Serum Concentrations in Pediatric Patients with Current Dosing Guidelines
Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...
متن کاملA Prospective Study to Assess Vancomycin Serum Concentrations in Pediatric Patients with Current Dosing Guidelines
Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...
متن کاملEvaluation of vancomycin dosing and corresponding drug concentrations in pediatric patients.
OBJECTIVE To describe the relationships between dosing strategy, age, and vancomycin trough concentrations in pediatric patients. METHODS This is a retrospective review of hospitalized pediatric patients between 2 months and 17 years of age treated with intravenous vancomycin from 2008 to 2011. The primary outcome was the number of patients achieving a target trough concentration of 10 to 20 ...
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Background. The pharmacokinetics of many medications change as we age, thus most would assume dosing strategies would adjust for these changes. The objective of this study is to evaluate the initial vancomycin dosing in three pediatric age groups based on measured serum trough concentrations. Methodology. This retrospective database review included patients aged from 1 month to 18 years old adm...
متن کاملEvaluation of Vancomycin Dosing and Corresponding Drug Concentrations in Pediatric Patients
ABBREVIATIONS AUC: area under the curve IDSA: Infectious Diseases Society of America MIC: minimum inhibitory concentration MRSA: methicillin-resistant Staphylococcus aureus SCr: serum creatinine VIN: vancomycin-induced nephrotoxicity Dr Geerlof wrote the fi rst draft of the manuscript and made substantive contributions to the study; Dr Boucher made substantive contributions to the study; and bo...
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